always up to date

Latest news

PRINCIPAL INVESTIGATOR / PhD

Tom Vanden Berghe

Professor Tom Vanden Berghe earned his Master's and PhD in Science (Biotechnology) in 1999 and 2005, respectively. Following his doctoral studies, he pursued postdoctoral research at the VIB-UGent Center for Inflammation Research. In 2018, he was appointed as an Assistant Professor at the University of Antwerp and as a Guest Professor at Ghent University. In 2023, he was promoted to an Associate Professor.

Professor Vanden Berghe is head of the Cell Death Signaling Lab at University of Antwerp. His mission is to conduct applied research focusing on cell death, particularly ferroptosis, pyroptosis (inflammation), and associated diseases. The Vanden Berghe Lab investigates mechanisms, diagnostics, and intervention strategies related to critical illnesses, brain injuries, kidney and vascular diseases. In addition, the team explores the potential of ferroptosis as a novel anti-cancer therapy for eliminating therapy-resistant cancers. Professor Vanden Berghe has established a comprehensive ferroptosis platform encompassing novel lead ferroptosis inhibitors and genes, ferroptosis diagnostics, and ferroptosis-based nanomedicine for anti-cancer therapeutics.

meet our team

Lab members

University of Antwerp
DSC 0353 copy

Tom Vanden Berghe, PhD

PRINCIPAL INVESTIGATOR

Professor @ UAntwerp
Guest Professor @ UGent

LEO0926 v2

Anja Verhulst, PhD

Team leader

Research coordinator
10% ZAP
Vascular calcification

2011 Benjamin Vervaet MR

Benjamin Vervaet, PhD

Team leader

Postdoctoral fellow
10% ZAP
Kidney disease

WhatsApp Image 2020 10 12 at 20.06.18

Behrouz Hassannia, PhD

Teamleader

Ferroptosis
Anti-cancer therapeutics

Britt

Britt Opdebeeck, PhD

Postdoctoral fellow

Mechanisms of vascular calcification

WhatsApp Image 2020 09 29 at 20.52.20

Emily Van San, PhD

Postdoctoral fellow

Ferroptosis
Multiple sclerosis

Profile picture Roberto Fernandez Acosta v2

Roberto Fernandez Acosta, PhD

Postdoctoral fellow

Ferroptosis
Epigenetics

Lies c

Lies Moonen

PhD student

Nephrectomy induced repair

sylvina 1

Sylvina da Silva Fernandes

PhD Student

Ferroptosis
Chronic interstitial nephritis

image001 v2

Cedric Peleman

Phd student

Ferroptosis
Nonalcoholic fatty liver disease

ine 1

Ine Koeken

PhD student

Ferroptosis
Anti-cancer therapeutics

Astrid Van den Branden 2

Astrid Van den Branden

PhD student

Ferroptosis
Chronic kidney disease

B66F4250 A38D 4174 A14D C70CBF211BA3 1 201 a

Geraldine Veeckmans

PhD student

Ferroptosis
Ischemia/reperfusion injury

magali

Magali Walravens

PhD student

Ferroptosis
Mechanism lipid peroxidation

Saar DSC 3704

Saar Adriaensen

PhD Student

Endothelial cells
Vascular calcification

image copy

Elien Van Campen

PhD student

Nephrectomy
Regeneration

Cyril v2

Cyril Willemart

PhD student

Precision medicine 2.0 diagnostics
Nanopore episequencing cfDNA
Critical illness

2007 Rita Marynissen MR

Rita Marinyssen

Technician

Administration
Biochemical analysis

2007 Hilde Geryl MR

Hilde Geryl

Technician

Experimental surgery
Bone histomorphometry
Biochemical analysis

2007 Ludwig Lamberts MR

Ludwig Lamberts

Technician

Biomedical Laboratory
Spectrometric Analyses

2013 Geert Dams

Geert Dams

Technician

Experimental surgery
Animal follow-up
Bone histomorphometry

Former lab members
2017 Gerd 5416 MR

Gerd Schreurs

PhD student

Toxin induced nephropathy

WhatsApp Image 2020 08 31 at 16.42.30

Geoffrey Van Den Bergh

PhD student

Arterial stiffness in vascular calcification

Raphaelle

Raphaëlle Corremans

PhD student

Metformin
Chronic kidney disease

Perez Novo C

Claudina Perez Novo, PhD

Postdoctoral fellow

Ferroptosis
Anti-cancer therapeutics

39DEC982 ACC6 4DB0 AE61 A4A927A42882

Bartosz Wiernicki

PhD student

Ferroptosis
Immunogenicity

profielfoto

Samya Van Coillie

PhD student

Ferroptosis
Multi organ failure

Men grey

Sze Men Choi

Technician

Experimental surgery
Mouse manager
Standard lab analysis

2005 Geert Behets MR

Geert Behets, PhD

Teamleader

Postdoctoral fellow
Bone histomorphometry

DDW Pasfoto 2017 5207 VL v2

Dirk De Weerdt

Graphical support

principal investigator / PhD

Publications

More on Google Scholar
Title Cited by
2024
Improving cardiac differentiation of human pluripotent stem cells by targeting ferroptosis
J Aalders, L Léger, B Hassannia, V Goossens, TV Berghe, J van Hengel
Regenerative therapy 27, 21-31, 2024
0
2024
THU-249 The role of the ferroptosis brake glutathione peroxidase 4 in a preclinical model of metabolic dysfunction-associated steatohepatitis
C Peleman, G Veeckmans, B Hassannia, L Vits, E Van San, J De Man, ...
Journal of Hepatology 80, S581-S582, 2024
0
2024
Ferroptosis in Health and Disease
C Berndt, H Alborzinia, VS Amen, S Ayton, U Barayeu, A Bartelt, H Bayir, ...
Redox Biology, 103211, 2024
0
2024
RIPK1 protects naive and regulatory T cells from TNFR1-induced apoptosis
J Huysentruyt, W Steels, M Ruiz Perez, B Verstraeten, M Vadi, T Divert, ...
Cell Death & Differentiation, 1-13, 2024
0
2024
Therapeutic exploitation of ferroptosis
M Walravens, I Koeken, T Vanden Berghe
Biochemical Society Transactions 52 (2), 693-706, 2024
0
2024
Emerging role of ferroptosis in metabolic dysfunction-associated steatotic liver disease: revisiting hepatic lipid peroxidation
C Peleman, S Francque, TV Berghe
EBioMedicine 102, 2024
1
2024
Reducing reagent-resistant transferrin receptor 1 dimer is a specific marker for ferroptosis
J He, M Kelleher, L Reynolds, H Tanczos, Z Huang, B McLaughlin, ...
Cancer Research 84 (6_Supplement), 357-357, 2024
0
2024
Loss of PPARα function promotes epigenetic dysregulation of lipid homeostasis driving ferroptosis and pyroptosis lipotoxicity in metabolic dysfunction associated Steatotic …
C Theys, T Vanderhaeghen, E Van Dijck, C Peleman, A Scheepers, ...
Frontiers in molecular medicine 3, 1-19, 2024
0
2023
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
C Scarpellini, G Klejborowska, C Lanthier, B Hassannia, TV Berghe, ...
Trends in Pharmacological Sciences, 2023
18
2023
A Guide to Ferroptosis, the biological rust of cellular membranes
G Veeckmans, E Van San, T Vanden Berghe
The FEBS Journal, 2023
1
2023
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
P Puylaert, L Roth, M Van Praet, I Pintelon, C Dumitrascu, A van Nuijs, ...
Angiogenesis 26 (4), 505-522, 2023
13
2023
Ferroptosis and pyroptosis signatures in critical COVID-19 patients
C Peleman, S Van Coillie, S Ligthart, SM Choi, J De Waele, P Depuydt, ...
Cell Death & Differentiation 30 (9), 2066-2077, 2023
9
2023
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
E Van San, AC Debruyne, G Veeckmans, YY Tyurina, VA Tyurin, H Zheng, ...
Cell Death & Differentiation 30 (9), 2092-2103, 2023
13
2023
Zonated quantification of immunohistochemistry in normal and steatotic livers
C Peleman, WH De Vos, I Pintelon, A Driessen, A Van Eyck, ...
Virchows Archiv 482 (6), 1035-1045, 2023
3
2023
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud, SA Aaronson, JM Abrams, D Adam, ...
Cell Death & Differentiation 30 (5), 1097-1154, 2023
108
2023
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
HP Van Eeckhoutte, C Donovan, RY Kim, TM Conlon, M Ansari, H Khan, ...
European Respiratory Journal 61 (4), 2023
17
2023
Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells
R Fernández-Acosta, B Hassannia, J Caroen, B Wiernicki, ...
Cells 12 (5), 735, 2023
6
2023
Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues
S Solier, M Mondini, L Meziani, A Jacquel, C Lacout, TV Berghe, Y Julé, ...
International Journal of Molecular Sciences 24 (4), 4151, 2023
1
2022
Zonated quantification of immunohistochemistry in steatotic livers
C Peleman, W De Vos, I Pintelon, A Driessen, C Van Steenkiste, ...
Journal of Hepatology 77, S709, 2022
0
2022
Correction to: Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen–glucose Deprivation
E Van Breedam, A Nijak, T Buyle-Huybrecht, J Di Stefano, M Boeren, ...
Neurotherapeutics 19 (4), 1433, 2022
0
total citations
35435
h-index
65
i10-index
99

Patents

Number Name Date
US9862678, WO2016075330, EP3218357 3,4-diaminobenzenesulfonamide derivatives for inhibiting cell death 2014-11-14
WO2019154795, EP3749645, CN112105601, US20210094909, 201980012162.8 3-(benzylamino)-4-(cyclohexylamino)-n-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 analogues as cell death inhibitors for treating e.g. stroke 2018-02-07
WO2015110346, US9919048 Targeting of interleukin-1 and -18 signaling in treatment of septic shock 2014-01-21
EP22196811 New Ferroptosis Inhibitors 2022-09-21