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PRINCIPAL INVESTIGATOR / PhD

Tom Vanden Berghe

Professor Tom Vanden Berghe earned his Master's and PhD in Science (Biotechnology) in 1999 and 2005, respectively. Following his doctoral studies, he pursued postdoctoral research at the VIB-UGent Center for Inflammation Research. In 2018, he was appointed as an Assistant Professor at the University of Antwerp and as a Guest Professor at Ghent University. In 2023, he was promoted to an Associate Professor.

Professor Vanden Berghe is head of the Cell Death Signaling Lab at University of Antwerp. His mission is to conduct applied research focusing on cell death, particularly ferroptosis, pyroptosis (inflammation), and associated diseases. The Vanden Berghe Lab investigates mechanisms, diagnostics, and intervention strategies related to critical illnesses, brain injuries, kidney and vascular diseases. In addition, the team explores the potential of ferroptosis as a novel anti-cancer therapy for eliminating therapy-resistant cancers. Professor Vanden Berghe has established a comprehensive ferroptosis platform encompassing novel lead ferroptosis inhibitors and genes, ferroptosis diagnostics, and ferroptosis-based nanomedicine for anti-cancer therapeutics.

meet our team

Lab members

University of Antwerp
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Tom Vanden Berghe, PhD

PRINCIPAL INVESTIGATOR

Professor @ UAntwerp
Guest Professor @ UGent

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Anja Verhulst, PhD

Team leader

Research coordinator
10% ZAP
Vascular calcification

2011 Benjamin Vervaet MR

Benjamin Vervaet, PhD

Team leader

Postdoctoral fellow
10% ZAP
Kidney disease

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Behrouz Hassannia, PhD

Teamleader

Ferroptosis
Anti-cancer therapeutics

Britt

Britt Opdebeeck, PhD

Postdoctoral fellow

Mechanisms of vascular calcification

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Emily Van San, PhD

Postdoctoral fellow

Ferroptosis
Multiple sclerosis

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Roberto Fernandez Acosta, PhD

Postdoctoral fellow

Ferroptosis
Epigenetics

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Lies Moonen

PhD student

Nephrectomy induced repair

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Sylvina da Silva Fernandes

PhD Student

Ferroptosis
Chronic interstitial nephritis

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Cedric Peleman

Phd student

Ferroptosis
Nonalcoholic fatty liver disease

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Ine Koeken

PhD student

Ferroptosis
Anti-cancer therapeutics

Astrid Van den Branden 2

Astrid Van den Branden

PhD student

Ferroptosis
Chronic kidney disease

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Geraldine Veeckmans

PhD student

Ferroptosis
Ischemia/reperfusion injury

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Magali Walravens

PhD student

Ferroptosis
Mechanism lipid peroxidation

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Saar Adriaensen

PhD Student

Endothelial cells
Vascular calcification

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Elien Van Campen

PhD student

Nephrectomy
Regeneration

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Cyril Willemart

PhD student

Precision medicine 2.0 diagnostics
Nanopore episequencing cfDNA
Critical illness

2007 Rita Marynissen MR

Rita Marinyssen

Technician

Administration
Biochemical analysis

2007 Hilde Geryl MR

Hilde Geryl

Technician

Experimental surgery
Bone histomorphometry
Biochemical analysis

2007 Ludwig Lamberts MR

Ludwig Lamberts

Technician

Biomedical Laboratory
Spectrometric Analyses

2013 Geert Dams

Geert Dams

Technician

Experimental surgery
Animal follow-up
Bone histomorphometry

Former lab members
2017 Gerd 5416 MR

Gerd Schreurs

PhD student

Toxin induced nephropathy

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Geoffrey Van Den Bergh

PhD student

Arterial stiffness in vascular calcification

Raphaelle

Raphaëlle Corremans

PhD student

Metformin
Chronic kidney disease

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Claudina Perez Novo, PhD

Postdoctoral fellow

Ferroptosis
Anti-cancer therapeutics

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Bartosz Wiernicki

PhD student

Ferroptosis
Immunogenicity

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Samya Van Coillie

PhD student

Ferroptosis
Multi organ failure

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Sze Men Choi

Technician

Experimental surgery
Mouse manager
Standard lab analysis

2005 Geert Behets MR

Geert Behets, PhD

Teamleader

Postdoctoral fellow
Bone histomorphometry

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Dirk De Weerdt

Graphical support

principal investigator / PhD

Publications

More on Google Scholar
Title Cited by
2023
Beyond ferrostatin-1: a comprehensive review of ferroptosis inhibitors
C Scarpellini, G Klejborowska, C Lanthier, B Hassannia, TV Berghe, ...
Trends in Pharmacological Sciences, 2023
3
2023
A Guide to Ferroptosis, the biological rust of cellular membranes
G Veeckmans, E Van San, T Vanden Berghe
The FEBS Journal, 2023
0
2023
Ferroptosis and pyroptosis signatures in critical COVID-19 patients
C Peleman, S Van Coillie, S Ligthart, SM Choi, J De Waele, P Depuydt, ...
Cell Death & Differentiation 30 (9), 2066-2077, 2023
3
2023
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression
E Van San, AC Debruyne, G Veeckmans, YY Tyurina, VA Tyurin, H Zheng, ...
Cell Death & Differentiation 30 (9), 2092-2103, 2023
5
2023
Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques
P Puylaert, L Roth, M Van Praet, I Pintelon, C Dumitrascu, A van Nuijs, ...
Angiogenesis, 1-18, 2023
5
2023
Apoptotic cell death in disease—Current understanding of the NCCD 2023
I Vitale, F Pietrocola, E Guilbaud, SA Aaronson, JM Abrams, D Adam, ...
Cell Death & Differentiation, 1-58, 2023
58
2023
RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD
HP Van Eeckhoutte, C Donovan, RY Kim, TM Conlon, M Ansari, H Khan, ...
European Respiratory Journal 61 (4), 2023
15
2023
Molecular mechanisms of nemorosone-induced ferroptosis in cancer cells
R Fernández-Acosta, B Hassannia, J Caroen, B Wiernicki, ...
Cells 12 (5), 735, 2023
4
2023
Caspase inhibition modulates monocyte-derived macrophage polarization in damaged tissues
S Solier, M Mondini, L Meziani, A Jacquel, C Lacout, TV Berghe, Y Julé, ...
International Journal of Molecular Sciences 24 (4), 4151, 2023
1
2023
Zonated quantification of immunohistochemistry in normal and steatotic livers
C Peleman, WH De Vos, I Pintelon, A Driessen, A Van Eyck, ...
Virchows Archiv, 1-11, 2023
3
2022
Zonated quantification of immunohistochemistry in steatotic livers
C Peleman, W De Vos, I Pintelon, A Driessen, C Van Steenkiste, ...
Journal of Hepatology 77, S709, 2022
0
2022
Correction to: Luminescent Human iPSC-Derived Neurospheroids Enable Modeling of Neurotoxicity After Oxygen–glucose Deprivation
E Van Breedam, A Nijak, T Buyle-Huybrecht, J Di Stefano, M Boeren, ...
Neurotherapeutics 19 (4), 1433, 2022
0
2022
Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity
B Wiernicki, S Maschalidi, J Pinney, S Adjemian, T Vanden Berghe, ...
Nature communications 13 (1), 3676, 2022
103
2022
Novel iron oxide nanoparticles induce ferroptosis in a panel of cancer cell lines
R Fernández-Acosta, C Iriarte-Mesa, D Alvarez-Alminaque, B Hassannia, ...
Molecules 27 (13), 3970, 2022
24
2022
Inhibiting RIPK1 kinase activity is protective in experimental models of COPD
HP Van Eeckhoutte, C Donovan, R Kim, H Khan, R Jayaraman, ...
ERJ Open Research 8 (suppl 8), 2022
2
2022
Luminescent human iPSC-derived neurospheroids enable modeling of neurotoxicity after oxygen–glucose deprivation
E Van Breedam, A Nijak, T Buyle-Huybrecht, J Di Stefano, M Boeren, ...
Neurotherapeutics 19 (2), 550-569, 2022
9
2022
Targeting ferroptosis protects against experimental (multi) organ dysfunction and death
S Van Coillie, E Van San, I Goetschalckx, B Wiernicki, B Mukhopadhyay, ...
Nature communications 13 (1), 1046, 2022
60
2022
Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state
F Ghazavi, J Huysentruyt, J De Coninck, S Kourula, S Martens, ...
Proceedings of the National Academy of Sciences 119 (6), e2024508119, 2022
9
2021
Necroptosis signaling promotes inflammation, airway remodeling, and emphysema in chronic obstructive pulmonary disease
Z Lu, HP Van Eeckhoutte, G Liu, PM Nair, B Jones, CM Gillis, ...
American journal of respiratory and critical care medicine 204 (6), 667-681, 2021
91
2021
Ferroptosis: biological rust of lipid membranes
B Hassannia, S Van Coillie, T Vanden Berghe
Antioxidants & Redox Signaling 35 (6), 487-509, 2021
48
total citations
33721
h-index
63
i10-index
95

Patents

Number Name Date
US9862678, WO2016075330, EP3218357 3,4-diaminobenzenesulfonamide derivatives for inhibiting cell death 2014-11-14
WO2019154795, EP3749645, CN112105601, US20210094909, 201980012162.8 3-(benzylamino)-4-(cyclohexylamino)-n-(2-(piperazin-1-yl)ethyl)benzenesulfonamide derivatives and related ferrostatin-1 analogues as cell death inhibitors for treating e.g. stroke 2018-02-07
WO2015110346, US9919048 Targeting of interleukin-1 and -18 signaling in treatment of septic shock 2014-01-21
EP22196811 New Ferroptosis Inhibitors 2022-09-21