-
Decode the molecular, metabolic and lipid pathways governing ferroptosis
-
Investigate its links with immunity, inflammation and tissue regeneration
-
Identify mechanisms of cancer resistance, tissue vulnerability and ferroptosis biomarkers
1
Mechanistic understanding
2
Discovery phase
-
Identify ferroptosis regulators through genome-wide CRISPR and functional screening
-
Discover compounds that induce, inhibit or sensitise cells to ferroptosis
-
Develop blood- and sequencing-based diagnostic technologies
3
Preclinical validation
-
Induce ferroptosis to eliminate therapy-resistant cancers
-
Inhibit ferroptosis to protect vulnerable organs
-
Validate targeted delivery and combination treatments in advanced disease models
4
Clinical translation
-
Profile ferroptosis and pyroptosis in critically ill patients
-
Use cell-free DNA and nanopore sequencing to detect tissue-specific injury
-
Validate biomarkers for patient stratification and treatment monitoring
5
Industry & services
-
Cell-based compound screening and mechanistic validation
-
Preclinical efficacy testing in established disease models
-
Metal analysis and specialised bone histomorphometry