EWCD Program 2025
Sunday, May 11 2025
15:00-19:30 Registration
20:30 Dinner
Monday, May 12 2025
8:45 Welcome
Cell death mechanisms and decision making
Chairs: Monika Yabal and Tom Vanden Berghe
9:00 Cristina Muñoz Pinedo: When stressed cells don't die: LIF release, stimulated by metabolic stress, promotes
tumor growth
9:15 Tom Delanghe: TAB2 controls a TAK1-independent cell death checkpoint at the level of TNFR1 complex II in the
TNF pathway
9:30 Anna Crois: Exploring the multifaceted roles of caspase-8 in cell death and TNFR1 complex II interactome
characterization
9:45 Fabian Wohlfromm: Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic
networks
10:00 Asma Majoul: Decoding necroptosis through optogenetics: Investigating MLKL activation and membrane
repair in cell death decision-making
10:15 Joëlle Hornebeck: Mammalian TeTIR-Containing ATPases Resemble Plant TNL/TNP Receptors and Induce Cell
Death via NADase Activity
10:30 Coffee Break
Inflammation and the inflammasome
Chairs: Annika Meinander and Cian D'Arcy
10:45 Motti Gerlic: The role of a novel RIPK2 mutation in immunoinflammatory disease
11:00 Yasmin Carvalho Schäfer: A shorter splicing isoform antagonizes ZBP1 to modulate cell death and
inflammatory responses
11:15 Zhehao Paul Tan: GSDMD and GSDME amplify NLRP3 activation in autoinflammation
11:30 Andreas Damianou: UCH-L1 as a modulator of NLRP3 inflammasome activation and IL-1β secretion
11:45 Sergio García Sánchez: Unraveling the role of LC3-independent autophagy in intestinal inflammation
12:00 Mark Mellett: RIG-I-like receptor activation induces Gasdermin E-dependent IL-36γ release from human
primary keratinocytes – implications for inflammatory skin disease12:15 Lunch
Cell death and signaling induced by nucleic acid recognition
Chairs: Mads Gyrd Hansen and Lisa Hohorst
14:30 Gianmaria Liccardi: STING-activation-induces necroptosis independently of TNFR1
14:45 Nathalia M. de Vasconcelos: IAPs control ZBP1-dependent cell death
15:00 Chiara Cipollina: Double-stranded RNA-induced macrophage death: Molecular mechanisms and impact on
lung fibroblast activation
15:15 Hassan Rakhsh-Khorshid: Investigating the role of STING signalling in the development and pathogenesis of
pancreatic ductal adenocarcinoma
15:30 Johanna Seiler: Role of ZBP1 in human cells
15:45 Coffee break
Ferroptosis and its interplay with other forms of cell death
Chairs: Carlos Alvarez and Nathalia M. de Vasconcelos
16:00 Tom Vanden Berghe: Ferroptosis targeting protects against graft injury during experimental liver and lung
transplantation
16:15 Juliana Hüther: Interplay of ferroptotic and apoptotic cell death and its modulation by BH3-mimetics
16:30 Chenxi Xu: Addressing the in vivo relevance of system xc-
16:45 Anuschka Langpape: Therapeutic induction of ferroptosis shows additive effects with Ibrutinib in diffuse large
B-cell lymphoma (DLBCL)
17:00 Roberto Fernández Acosta: Epigenetic reconditioning of ferroptosis-resistant high-risk neuroblastoma:
Hacking the tumor defense machinery
17:15 Dave Boucher: It takes two to tango: Ferroptosis and pyroptosis control response to intracellular LPS
18:30 Poster session I (odd numbers)
20:30 Dinner
Tuesday, May 13 2025
Mitochondria and inflammation
Chairs: Markus Morrison and Doğa Aşık9:00 Joel Riley: Decoding the inflammatory nature of mitochondrial cell death
9:15 Lisa Hohorst: Gasdermin E-mediated mtDNA release from apoptotic mitochondria
9:30 Keely Caplen: Investigating the mechanism in which XIAP regulates mtDNA release
9:45 Denis Grigorev: The cell-intrinsic and -extrinsic roles of XIAP in intestinal T cell functions
10:00 Hannah Glover: Non-lethal apoptotic stress as an oncogenic consequence of a high fat diet: understanding
how obesity causes cancer
10:15 Lyndsey Flanagan: MitoSOS: Mitochondrial sub-lethal oncogenic signalling
10:30 Coffee break
Breaking barriers: pores, calcium, and cell death
Chairs: James Vince and Asma Majoul
10:45 Katia Cosentino: Structure and function of early-stage Gasdermin D oligomers
11:00 Nadine Gehle: Dynamics and structure of Gasdermin E pores at mitochondrial membranes during cell death
11:15 Eric Pérez Rivera: Role of calcium microdomains in regulated necrosis
11:30 Uris Ros: The specific code of membrane damage during regulated necrosis
11:45 Carlos Alvarez Valcarcel: Intracellular molecular concert orchestrated by the pore-forming protein sticholysinII
12:00 Nadin Kinz: Sub-lethal mitochondrial permeabilisation as a driver of B cell mutagenesis and oncogenic
transformation
12:15 Lunch
TNF signaling and linear ubiquitination
Chairs: Lynn Wong and Felix Eichin
14:30 Nieves Peltzer: Linear ubiquitination influences metabolic health
14:45 Frederik Timmermann: LUBAC PUB domain interactions restrict Met1-linked ubiquitin for optimal receptor
signalling, and protect from embryonic lethality and TNF toxicity
15:00 Rune Busk Damgaard: M1-linked ubiquitination by LUBAC regulates AMPK activity and cell death in response
to energetic stress
15:15 Jon Huyghe: Endosomal micro-autophagy prevents TNF cytotoxicity by detoxifying TNFR1 complex II
15:30 Biao Ma: An upstream ORF controls TNFR1 abundance and tissue tolerance to TNF
15:45 Annika Meinander: M1-ubiquitination of the Drosophila caspase Dredd promotes NF-κB activation by
protection of the IKK complex
16:00 Coffee BreakThe many faces of cell death and diseases
Chairs: Simone Di Franco and Laura Martínez Escardó
16:15 Jan Paul Medema: Enterocyte-like differentiation defines metabolic gene signatures of CMS3 colorectal
cancers and provides therapeutic vulnerability
16:30 Mabel Cruz Rodriguez: The unfolded protein response mediates the balance between homeostasis and cell
death in glucose-starved lung adenocarcinoma cells
16:45 Laurie Clauzon: Characterization of epithelial/mesenchymal phenotype in chemoresistance of esophageal
adenocarcinoma cells
17:00 Giulia Bozzari: Metabolic adaptive responses underlying the progression of thyroid cancer
17:15 Federico Lucantoni: ROCK1 activation enhances the occurrence of cellular cannibalism via entosis
17:30 Adrian Ting: Sensitizing solid tumors to paracrine killing by T cells
18:30 Poster session II (even numbers)
20:30 Dinner
Wednesday, May 14 2025
Decoding BCL-2 family in apoptosis and cancer evasion
Chairs: Caroline Mauvezin and Fabian Wohlfromm
9:00 Joanna Fox: Phospho-inhibition of pro-apoptotic effector protein BAK is mediated by the SH3 domain of BMX
tyrosine kinase
9:15 Christina Elsner: Unveiling the molecular details of inhibition of proapoptotic proteins at the membrane
9:30 Ali Jazaeri Jouneghani: Molecular mechanism of BOK mRNA stability regulation via TRIM28 protein
9:45 Laura Martínez Escardó: New insights into BCL-2 family protein expression and dependency in prostate cancer
10:00 Clara Alcon: Apoptotic protection in therapy-induced senescent cancer cells
10:15 Ben Croker : GSDME promotes PAD4 activation and DNA externalization from apoptotic neutrophils
10:30 Coffee Break
DNA damage and chromosomal instability
Chairs: Joanna Fox and Mark Mellett
11:00 Rotraud Hirschberger: Defining the substrate specificity of caspase-2
11:15 Felix Eichin : Consequences of impaired PIDD1 auto-processing on PIDDosome function11:30 Aislinn Gallagher Aldave: Exploring the role of Bcl-2 family proteins in regulating entry to DNA damage-
induced replicative senescence
11:45 Caroline Mauvezin: Mitotic catastrophe induced by autophagy dysregulation: insights into chromosomal
instability and cancer therapy
12:00 Frontiers: Peer Review: methods and ethics
12:15 Lunch
14:00 Free time - Spa or Tour of Fiuggi inner city
19:30 Wine tasting
20:30 Dinner with round table discussions
Thursday, May 15 2025
Emerging therapies and future directions
Chairs: Michael Hahne and Iswarya Sreeram
9:00 Lukas Meisinger: Targeting LRH-1-regulated survival processes in acute lymphoblastic T cell leukemia
9:15 James Vince: Engineering multi-targeted biodegrader intrabodies to modulate distinct cell death modalities
9:30 Louise Ramos: Modeling activity of next-generation DDR inhibitors in a physiologically relevant 3D printed bone
matrix
9:45 Ciro Longobardi: Hitting the Achilles' heel of mesenchymal colorectal cancer: Targeting RUVBL1/2
10:00 Manuel Beltrán Visiedo: Mitochondrial involvement in the cytotoxicity and immunogenicity of radiation
therapy in breast cancer
10:15 Mads Daugaard: Targeting oncofetal chondroitin sulfate in solid tumors
10:30 Coffee Break
Game changing ways to obliterate tumor cells
Chairs: Nieves Peltzer and Eric Perez
11:00 Seamus Martin: Cytotoxic chemotherapy-induced cell death versus cell senescence: What doesn’t kill you
makes you stranger
11:15 Milagros Buffa Oviedo: Advancing lung cancer therapy by modulating BOK
11:30 Britt van der Swaan: Towards a novel therapy for multiple myeloma by identification of sensitizers for the
BCL-2 inhibitor Venetoclax
11:45 Cian D'Arcy: Global proteomic assessment of a novel HDAC6 inhibitor in multiple myeloma12:00 Kimiya Shams: Combinatorial therapy based on CD44v6 inhibitor AMC303 for the treatment of metastatic
colorectal cancer
12:15 Lunch
Cell death in cancer transformation
Chairs: Joan Montero and Daniela Stöhr
14:30 Demi Both: Killing of malignant B cells by bispecific antibodies or CAR T cells contains a necroptotic arm which
affects the release of immunomodulatory molecules
14:45 Philippe JeanRichard: The link of BOK to uridine metabolism and cancer
15:00 Annagiada Toniolo: Mechanistic contribution of different cell death modalities to neoplastic responses in
squamous carcinogenesis
15:15 Mohamed Elmesery: Inhibition of mitochondrial respiration sensitizes hepatocellular carcinoma cells to
TRAIL-induced apoptosis by switching from Type II to Type I signaling
15:30 Beatrice Dufrusine: BAG3 drives metabolic reprogramming in tumor-associated fibroblasts, promoting
extracellular matrix remodeling and tumor progression
16:30 Football Tournament
20:30 Gala Dinner
Friday, May 16 2025
DeparturePoster
No.
Name 1 Abraar 2 Alessandro 3 Angelo 4 Anja 5 Baltramiejus 6 Caitlin 7 Carlo 8 Carmen 9 Cecilia 10 Chiara 11 Chloé 12 Christine 13 Christophe 14 Claudia Aracelis 15 Dalal 16 Eman 17 Emma 18 Erika Surname Patel Giammona Peschiaroli Bosnjak Jakštys Ross Rodolfo Soto Pesini Martin Cipollina Pangault Kiefer Le Clorennec Plasencia
Iglesias
Morad Alshehri Díaz Piñero Pizzinato Poster title
Identification of activation-sensitive epitopes in
pro-apoptotic effector protein BAK in situ
Succisa pratensis treatment induces
chemotherapy sensibility in glioblastoma cells
Role of the ABC transporter ABCC1 in squamous
carcinogenesis
Deciphering the role of Protein Tyrosine Kinase 7
(PTK7) in the bottom crypt fibroblasts in colon
homeostasis and pathologies
Annexin A4 protein contributes to active plasma
membrane repair mechanisms following in vitro
electric field application
Investigating the Structure and Dynamics of the
BAK Oligomer in Apoptotic Cell Death
Impact of TRK-Fused Gene (TFG) pathogenic
mutations on the regulation of autophagy and
mitochondria homeostasis: molecular
mechanisms and clinical opportunities.
MORE THAN A PORE: INTRACELLULAR
PATHWAYS AND DAMPs RELATED TO THE
REGULATED NECROSIS INDUCED BY STICHOLYSIN
II
Development of CART and CARNK cells for
hematological neoplasms expressing mutated
Calreticulin
Damage-associated molecular patterns (DAMPs)
released by macrophages exposed to cigarette
smoke and lipopolysaccharide promote steroid-
resistant inflammation
Protein tyrosine kinase 7 (PTK7) receptor
expression in a subset of fibroblasts regulates
colon homeostasis and pathologies
Mitotic cell death: The unexpected role of MLKL
The role of the deubiquitinase USP7 and the
E3/E4 ubiquitin ligase complex ITCH/UBE4B in
the regulation of cell death in neuroblastoma.
Interplay between endogenous calcium channels
and MLKL in necroptosis
Inhibition of tyrosine kinase BMX increases cell
death in response to existing chemotherapeutic
agents overcoming apoptotic resistance in TNBC
breast cancer survival.
Analysis of the Cdk1/ Bax Interaction during
Mitotic Checkpoint-Induced Apoptosis
Novel functional aspects of the SIGMAR1
involvement in cellular proteostasis
Neurodegeneration induced by High Fat Diet in
an Hyperinsulinemic Mouse Model19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 Gianluca Giulio Gloria candy
danielle
Gretchen Helen yarimet Iswarya Jenny Job Johannes Ka pui sharon Liyang Ludovica Lynn Nathan Markus Michael Michael Michèle Miriam Monica Mads Sala Lovato Sedoh Bergado Lorenzo-Anota Sreeram Geiger Kesselaar Espe Yau Wu Di Martino Wong Leborgne Morrison
(Rehm)
Hahne Schäfer Jost Beichler Yabal Gyrd-Hansen LGALS3BP Antibody-Drug Conjugate Enhances
Tumor-Infiltrating Lymphocytes and Synergizes
with Immunotherapy to Restrain Neuroblastoma
Growth
LGALS3BP’s role in bladder cancer: a potential
urinary biomarker and therapeutic target
Deciphering the dynamic assembly of Bax pores
at the mitochondrial membrane
Activation of intracellular calcium signalling in
response to the pore-forming toxin sticholysin II
Disulfiram-loaded nanoparticles induce
mitochondrial damage promoting regulated cell
death and long-term proliferation inhibition on
preadipocytes
Pseudo-senescence induced by palbociclib does
not sensitize pleural mesothelioma cells to
combinations with classical senolytics.
Assessing the impact of stochasticity in protein
distributions on mitochondrial apoptosis
susceptibility – a systems biological approach
Investigating the Potential of Zn, Ni, and Ag to
Induce the Copper Dependent Cell Death
Pathway, Cuproptosis.
Investigation of the role of c-FLIP isoforms in
CD95-mediated activation of NF-κB
The Coccidioides tri-factor: macrophage cell
death sensing of fungal conidia, spherules and
endospores
Targeting programmed death with small
molecule inhibitors for non-small cell lung cancer
Metabolic and Apoptotic Dependencies in
Multiple Myeloma: Insights into BCL-2
Dependency and Cellular Plasticity
What makes a cell sensitive to TNF?
Human NK cells activates non-canonical
inflammasome
Spatiotemporal regulation of MCL-1 abundance
and its influence on apoptosis susceptibility
Pyruvate-mediated modulation of primary cilia
biology in colonic fibroblasts
Metabolic control of neurite death in human
central nervous system neurons
Studying the underlying mechanisms of cell death
crosstalk dynamics in the combination of
chemotherapeutic drugs and TRAIL
The role of the Met1-linked ubiquitin machinery
in the immune biology of human keratinocytes
and fibroblasts
Cell death and microbiome sensing in the small
intestine
An upstream ORF controls TNFR1 abundance and
tissue tolerance to TNF40 41 42 43 44 45 46 47 48 49 50 51 Olivia Díaz Navarro Özgün doğa Aşık Ronaldo Rodrigues
Ribeiro
Sara De Domenico Simone Di Franco Sofia Remedia Vincenzo De Laurenzi Jerry Chipuk Fabian Fischer Daniela Stöhr Danis Thomas Mohammadreza Bayat Synergistic effect of NINJ1 on cell death mediated
by pore-forming proteins
Correlative Structural and Functional
Investigation of Gasdermin D Oligomers in their
native environment
Exploring chemotherapy-induced cell stress and
inflammation
Biological relevance of the long non-conding RNA
NEAT1 in SCC
NGFR-driven pathway: oncogene vs
oncosuppressor role during colorectal cancer
progression
The highly Effective Anti-Cancer Activity of
Natural Bioactive Molecules: A Novel Strategy for
Glioblastoma Treatment
Liver-specific BAG3 knockout delays chemically
induced hepatocellular carcinoma development
A gated hydrophobic funnel within BAX binds
bioactive lipids to potentiate pro-apoptotic
function
TBK1 and IKKε prevent premature cell death by
limiting the activity of both RIPK1 and NLRP3
death pathways
Cardiac glycosides lower the threshold for
caspase-8 activation and potentiate
responsiveness to TRAIL therapeutics
Utilizing BH3 mimetics to design preventative
therapy for Hepatocellular carcinoma in non-
steatotic and steatotic background
TRAF6 regulates AMBRA1 ubiquitination
interconnecting autophagy and ubiquitin
proteasome system
